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This thread shows that many people have tried out various SINGLE nutrients or supplements with various results by various people. The search for "magic bullets" for mood disorders stem from the practice of most conventional doctor to use SINGLE drugs to treat complex mental problems.
It is not unnatural to believe hat single nutrients or even a small combination of nutrients will do the same thing as drugs.
FIRST, drugs do not treat the causes of mood disorders, but simply mask symptoms without addressing the underlying causes of mood disorders.
SECONDLY, it is true that most of our neurotransmitters and hormones are derived from food sources, but psychiatrists and psychologist are not trained in nutritional biochemistry and hence are not in a position to understand the causes of mood disorders.
THIRDLY, one must not expect psychiatrists and psychologists to eagerly embrace nutritional biochemistry, because in the end there is not much money to be made from natural therapeutic agents that cannot be patented and monopolized on which these professions are based at present.
It must be understood that neurotransmitters are build up from a complex array of ingredients in food that have an intricate interdependence of various nutrients to the extent that even if one nutrient/factor is missing the metabolism cannot be completed.
In addition there is the principle of INDIVIDUALITY of one's BIOCHEMISTRY, that says that "one man's meat can be another man's poison". We are all biochemically different and hence we need individualized treatment for mood disorders.
I have elaborated this a further in: Hit or Miss Supplements for Depression .
Despite this, we do have a need to simplify therapy and search for factors that apply to MOST (but certainly not ALL) people with mood disorders. Here we come to Occam's Razor or the Law of Parsimony, or looking for simpler hypotheses that can explain the phenomenon under consideration.
This is, for the body to convert one set of molecules into another set of molecules, as in the conversion of tryptophan in food into serotonin, it will need biological energy as it source of energy to carry out its metabolism.
This is generally overlooked by most experts. If the body lack biological energy (Adenosinetriphosphate [ATP]) it cannot convert and manufacture the various neurotransmitters and hormones that affect our feelings.
It just happens to b the case that most people with mood disorders tend to have an insulin resistance problems. This means that the body have difficulties in converting carbohydrates into ATP, hence lack the energy to produce feel-good neurotransmitters. This is a disease not as yet recognized by conventional medicine, mainly because it cannot be treated by drugs, and only by nutritional means. A disease that cannot be treated by drugs is seldom recognized by allopathic medicine, for obvious reasons.
This has been known for many years by nutritional doctors and has been discussed under the general heading of hypoglycemia, since the middle of the last century.
Hypoglycemia, meaning low blood sugar levels is not an satisfactory term, as it is really means "unstable blood sugar levels". Not only that, but a failure to convert Glucose into ATP can also affect glycolysis (ten step conversion of glucose into pyruvate), before it enters the Krebs cycle (Citric Acid cycle) to produce ATP. This means people can have the symptoms of hypoglycemia, whilst having a normal glucose levels in a Glucose Tolerance Test. This condition is called Hypoglycia. Or "brain diabetes".
Look up the various types of hypoglycemia in the above article.
Dr George Samra of Kogarah Australia has designed a medical test for hypoglycemia as distinct from Diabetes. Hypoglycemia is the forerunner of diabetes, and knowing you have hypoglycemia gives a you an opportunity to, prevent the development of diabetes.
The brain which is entirely dependent on the supply of glucose as its only source of energy (ATP) is very sensitive to fluctuations in blood sugar levels. In insulin resistance the body tends to overproduce insulin - called hyperinsulinism - causing a dip in blood sugar levels. This is experienced as a brain starvation. It triggers the release of stress hormones into the blood - especially adrenaline and cortisol - which function to convert sugar stores in the body into glucose, so as to feed the brain again with glucose.
The excess and unpredictable release of adrenaline is experienced by the person as symptoms of mood disorders over which he/she has no conscious control. These hormones are responsible for self-medication in drug addiction, for the night-mares of Post Traumatic Stress Disorders, depression, anxiety, violence and so on. Hypoglycemia is associated with a myriad of other diseases - mental and physical, such as candida, fibromyalgia Crohns Disease, IRBS, dementia, schizophrenia an bipolar disorder, ADHD and so on. See: Silent Diseases and Mood Disorders
The advatage of this hypothesis is that treatment is simple and does not require pharmaceutical drugs. Simply adopt the hypoglycemic diet as a first step in treatment. And it is "evidence-based science".