No, I didn't see an increase in Acne with increased testosterone, but my testosterone is not that high. It has gotten into the normal range but is not overly high. I still deal with Acne on and off but I don't think it is related to testosterone levels. I suffer from bad anxiety, which could be because of deficiencies in neurotransmitters, which definitely depresses my immune system. I know I have liver issues - not only do i have some symptoms of it but one of the kinesiologists I see could tell through the muscle testing that my liver/gallbladder is causing me big problems.