no, it's not necessary to wait. i ate a ton of it after. you can try eating it. i like it in salsa. add it and see how you do for a few days, before adding a new chelator. you really should broaden your spectrum a little. selenium and calcium and magnesium, etc.... minerals are instrumental in getting it out of your brain. the brain thinks mercury is a mineral and it tries to hang on to it. you need an excess of minerals to get it to release from the brain. here is some chelation info.