Dr Clark says in her book that you should only stop the medication on the day of the cleanse. She emphasises that you do not give up any medication during the treatments and that you stay on them until your health is much improved and with medical opinion before you stop. I don't know anymore than this except because my husband is on blood pressure medication, beta blockers, medication for prostate and statins for cholesterol I gave him the lemon and oil cleanse rather than the Epsom Salts . He had a great result and is alive and kicking.