Re: Stages of MCS

CYP2D6 is one of many pathways of the P450 detoxification system. There are lots of them. For instance CYP2C9. I found several links that you could check out for more information.

List of meds and pathways:

http://medicine.iupui.edu/flockhart/table.htm


MCS and P450 CYP2D6:

http://www.protectingourhealth.org/newscience/immune/2004/2004-0715mckeown-ey...


""CYP2D6 (Cytochrome P450 2D6) encodes for enzymes that metabolize many toxic chemicals as well as therapeutic drugs (e.g., antidepressants, antipsychotics, beta blockers). Cytochrome P450 enzymes are a large family of enzymes that comprise an important part of the body’s tools to get rid of potentially harmful substances by making them more water-soluble. This study looked at four alleles of CYP2D6: *3, *4 and *5, all of which make CYP2D6 non-functional, and *1, the active form of CYP 2D6.""

A Canary's eye View on P450 metabolism:

http://www.loudzen.com/canary/metabolic_basis/detoxification/p450.html


MCS Canada P450 Info:

http://www.mcscanadian.org/p450.html


""Cytochrome P450s in Humans by David Nelson Ph.D. "Cytochrome P450 proteins in humans are drug metabolizing enzymes and enzymes that are used to make cholesterol, steroids and other important lipids such as prostacyclins and thromboxane A2. These last two are metabolites of arachidonic acid. Mutations in cytochrome P450 genes or deficiencies of the enzymes are responsible for several human diseases. Induction of some P450s is a risk factor in several cancers since these enzymes can convert procarcinogens to carcinogens..." ""


http://www.pharmacytimes.com/article.cfm?ID=2238


""Most Caucasians rapidly convert codeine to morphine via CYP2D6. Approximately 7% to 10% of Caucasians, however, have a genetic variant that produces limited CYP2D6 activity and slow metabolism of CYP2D6 substrates. ""



http://en.wikipedia.org/wiki/CYP2D6


""Cytochrome P450 2D6 (CYP2D6), a member of the cytochrome P450 mixed-function oxidase system, is one of the most important enzymes involved in the metabolism of xenobiotics in the body. Whilst CYP2D6 is involved in the oxidation of a wide range of substrates of all the CYPs, there is considerable variability in its expression in the liver.""


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