I would be curious to know if what you are referring to is a pharmaceutical premarin.. This is part of what docs prescribe for hrt. Made from pregnant horse urine and definitely not what I want in my body!! I swear by natural progesterone cream. I have lots of information on it as well as a yahoo group called itsmyhormones . Email me if you have questions and maybe I can help you. The idea of progesterone is to fight estrogen and level off your hormones. I have 2 good friends with PCOS who are trying the nhc to get pregnant and have heard wonderful results of pcos people using it!! I just can't imagine that the doc you were referring to was talking about a natural progesterone cream! Malinda