Hi, I was on Allegra D and haven't taken it since I started this cleanse and I am on Day 5. I have not had any allergy problems yet so the first day or two might be bad for you but it will get better. You are not suppose to take any meds with this diet unless it is life threatening if you don't take them. I've heard you can do anti-depressants if you need to. I would not take the appetite suppressant. Just keep on drinking the lemonade every time you get a hunger pang. I promise it gets easier and so does the salt water thing. I know it is disgusting but that will get easier to handle. You might be tired the first few days so take it easy. Good luck and hang in there