I too had a large stone. I tried and tried to dissolve it. It wouldn't flush and I was afraid if I kept trying to flush it, it might get stuck. I was in so much agony and pain that I finally relented and had my gallbladder out. I didn't want to take it out, believe me, but I couldn't stand the pain any more. So far, I have been just fine with no adverse side effects. I hope you have better luck than I did.