From the reading I have done, lots of flushes can be a bit taxing on the kidneys??? I wonder if just lots of distilled water and/or tea in between times could help this since it would help in flushing the system. I have been through 4 flushes and still can feel the gallbladder in there talking to me with all sorts of twitches and cramps. I have done 2 flushes back to back and seem no worse for the wear.