Colonix didn't work for me either. I too have an extremely slow system. I was lucky if I was able to have one bm per week. I have eaten a whole foods vegan diet for most of my life and tried every remedy known to man to help my chronic constipation, including several prescriptions which did little more than make me feel like I was going to vomit. Anyway, I believe I have discovered a miracle in Oxypowder . I cannot believe how good it feels to have a bm everyday! I don't have any recollection of ever being able to do that. I just started with the Oxypowder and I've been taking 6 capsules nightly. Let me put it to you this way, if this stuff cost $500 a bottle, I would get a second job to earn the money to buy it. No joke. The give you a money back guarantee anyway, so I'd say you really have nothing to lose.