Hi - enemas are not at all necessary I have found - the Oxypowder does a great job of liquifying and moving out the junk. I did not follow any diet other than what I normally follow - a kind of low carb protein power type diet. I had great success with Oxypowder . Much better than anything else I tried. One thing I would say though is that I feel 4 tabs is much too high a start for some folks. I've seen some people need to back up to 1-3 caps as the 4 was too hard for them. While some people can go up to 12 without feeling much, I've seen some folks have overly strong cleansing with 2. I really believe in starting slow and slowly building up. My husband only needed 3 a night to get a good cleanse going with the recommended bowel movements per day.