As for a better way to ingest that much I got 400mg caps either from the DrClarkStore.com or DrClark.com. Can't remember which but it makes it alot easier to take. I took 4000mg since I'm over 150lbs and then 1 cap/day for a week, then 4000mg again and finished off the bottle at 1 cap/day. The only effect I could notice was that I seemed to have an increase in energy but I was also doing the Master-Cleanse so I'm not sure exactly what caused it. probably a synergism of some sort. I haven't been able to find any negative effects in the literature. I'm thinking that you need the large doses for the parasite cleanse to overload the little buggers.