It totally depends on your goals and issues, but everyone can benefit from thorough colon cleansing and from a liver cleanse coupled with liver herbs, as our livers are SOOO important and like any filter need to be changed every now and again. :)
My liver notes and idyllic Liver Flush post give you some of your options. I don't recommend The Clark Flush , it's a whole lot of bother and Epsom Salts sometimes cause fake stones to form as it mixes with the olive oil.
For colon cleansing, P&B shakes are fantastic, but to get toxins out faster so you don't re-poison yourself it's best to also do enemas and/or colonics. Dr. Jensen's book is a great, fast read and available online here.