There are several antifungals for systemic use, nizoral, diflucan, lamisil (I believe there is a pill form available) and a few others which can be referenced in Dr. William Crook's books. Diflucan is usually well tolerated. Nizoral does a bang up job of killing the candida outright, but is hard on the liver. (You still will need to purge and cleanse the system afterward to balance, strengthen and bring lasting results.) All pharmaceutical systemic antifungals are metabolized through the liver and one should have regular tests for liver function while taking them. For these reasons most people employing a holistic approach to fight candidiasis avoid these agents. There is no one pill available that will "cure" candidiasis. These Rxs are good to get one over the hump, then lay off them. They need to be used in conjuction with diet & cleansing.