first I will say I have no liver disease per say but I was a bartendar for 8 years and drank more then my fair share for at least 10 years. I have been sobering up... drinking wine now and again,not like the wasted I was used to for many years.. regardless I have noticed over the years yellow fatty things on my eyes which I came to believe was from my liver not functioning completely right( since it has alot to do with fat/metabolism ) I started taking Milk thistle and took it for at least a month, it says not to miss a day or you will end up having to start all over again anyway now my eyes are clear no spots, well a little but I think I stopped to soon and have started again. I really notice a huge difference in how I feel after taking it for awhile. hope this helps.