Are you at the age to experience prostate problems?? You are experiencing a symptom of that. You seem to be taking a cocktail of stuff I am not totally familiar with but you should check with your physician to see if there are any interactions you are experiencing. It could be as simple as "kidney grit" however, although that too would require a visit to the doctor. Your problem is not just a matter of detoxing however and suggests something more serious.
Take care and do not wait too long to get it taken care of.