Red worms, Fenben or OXBen, Lung vs GI reproduction species
Different red worm species can go to two locations we have identified. Intestine or nasal. Lung mucus seems to be common for both, L2 stage.
We have identified others in our group, that react and respond to red meds, that have no sinus stage, or acid drip. Most of these tough strongyle like DNA worms, do not respond to FenBen, at even double doses.
OXBen is several times stronger, its Sulfur attraction to Nitrogen, draws the medicine towards worm locations. It also is easier in the body. Expect NOEL numbers to be about 17mg/kg/D. Use at 30mg/kg/D seems to vastly degrade these resistant strongyle species and filarials.
I have not yet mapped strongyle species to identifying symptoms.
I know the signature identifying symptom for Strongyles Vulgaris, is transient blood flow stoppage, Hand go numb for several minutes as the enter and leave blood vessel. Even under control, there is not fall to floor symptoms, but they still can cause sleeping hands, legs, Portal hypertension until they are restricted in numbers, by intensive treatment.
Filarials, we have mapped a few symptoms, but it seems identifying the family tree species is the first objective.
Then we can slowly map symptoms to species.
This could take years.
In years past, several approaches have been used to control REDS species.
Many meds work, and dosing is usually a high level.
In the early days, I took many meds from the reds list, and did them all at once.
That way lower doses could be done.
When Pyrantel, Levamisole, Piperazine citrate, FenBen, IVM, Moxi are all done at once, after 3 months of daily dosing there was a slow but steady improvement.
Later on, testing of high dose Pyrantel, Pyrantel FenBen, then Pyrantel levamisole was done.
Piperazine, Pyrantel and FenBen showed merit for short periods, till the PPZ caused side effects. nPPZ did not help.
Both Pyrantel and Levamisole, both AChE antagonists, seemed to control adult stages better.
Later we did Thyme, oregano, pine products, terpines, and a few others. After 3 months they allowed population increase, DEC had little effect on red filarials, but did work long term on white filarials/Ascaris. Doxy may have had an effect, this is unknown. Certainly the natural with the largest bang was Thyme, and for the human immune system Pine Needle oil was the most powerful addition to Formula 35 Revision Y10.
Finally now the formula that has received the most results, is OXBen, Thyme Vulgaris leaf, Wild oregano oil, Castor oil, Pine needle oil.
Adding B50, and doing a B3 sensitivity test, probably L carnitine sensitivity test to follow, and then low dose nPPZ.
This is a long term search for a solution to these strongyle species, and looking at long term supplements to make the process more sustainable seems to be the next phase of formula development, unless some new discovery comes along.
There are now Magnesium Sulfate capsule in the 100mg strength, they are the best form of organ support. Dr Clarks caps are too strong for years of use.
https://www.camformulas.com/Magnesium-Sulfate-100-caps-by-BioTech-Pharmacal-p/biotech-1100.htm
These are discontinued.
I suggest magnesium sulfate in a number 4 cap is ok, if the magnesium sulfate is powdered in a Krups grinder.