But here is the great thing with this new A.G.E. FORMULA which removes lipofuscin and glycation it means the atp and mitochondria work way better, which means more cellular energy, which means loads of people who have a wide variety of ailments are noticing huge improvements, so no reason that the cells will not start to produce the correct level of enzymes required, will report back in due course after my mum has been using this for a few months...