I would start with a ParaWellness Labs test for parasites. parasites are underestimated and you have to keep constant pressure on them. It is possible that they are resistant. If you need my protocol let me know via personal message. I have fine tuned it and it is working albeit slowly.
I use sodium bicarbonate to balance pH which works wonders for me. I address liver toxicity with a combination of things including milk thistle products, phosphatidylcholine, acupressure points.
Infections create massive oxidative stress and you have to control that. Antioxidants stop the oxidation.
I also use a zeolite product (resultsrna) that has been great to pick up the toxins and metals.
Make sure you are getting adequate minerals in the diet, magnesium is likely low. I like Doctor's Best High Absorption Mag.
You can try organic gelatin or bone broth if you are experiencing leaky gut, this contains the same amino acid profile as the lining. It is the only thing that has helped.
*diaclaimer: I am not a doctor so I cannot diagnose or treat you. This information should be considered educational and shared with your healthcare professional.