Supplementing with methyl groups can be helpful but getting methylation working ie up and running is the better option if you can do it which I cannot. Supplementing with methyl groups can help the liver and aid detox and it should help improve a persons mood if you can get enough of the needed nutrients which isn't always possible unfortunately because of what causes the problems which puts the body under terrible strain from toxins flooding into the bloodstream. Increased Intestinal Permeability Syndrome aka Leaky Gut usually goes along with all these problems.