For conditions like yours it might be wise to do it gradually with low dosage. Also take lots of vitamin C and eat plenty of red/blue/black berries or take supplements of Grape Seed Extract, bilberry extract for their proanthocyanidins which helps strengthen the circulatory system walls. If Serrapeptase is removing scar tissue you need to make sure the areas are strengthened and healed to prevent any undesirable consequences. These things will provide what your body needs to heal and as a side effect it should benefit your skin and bones. ie less wrinkles.