Bentonite does not stick to colon walls. for information from a knowledagable ( 30 years ) clay practitioner you can contact him or check out his website at eatonsearth.org .. I and about 30 folks I know have been using clay for 1-12 years with no issues or sticking.. Most can take meds 2-3 hours later post clay ingestion. I played with it and found I need to take meds at least 4 hours away from teh clay or they arent absorbed ( have no thyroid would go hypo with the 2 hour window not go hypo with a longer window ) .