Yes overworked adrenal glands throw the thyroid off big time. Candida is known to tire the endocrine glands because of the inflammation it causes.
Theres a lot of protocols out there and it really depends on how serious your case is.. If you used Antibiotics for strep/ear infections when you were younger or if you used Antibiotics for Acne then you might need to address biofilms in the gut.
Other advanced protocols involve chelation therapy and body detoxing.