I've done it - i.e. my doctor did it - and I have no regrets. I still do subcutaneous injections of DMPS(when I do it myself) or i.v. (when I went to the doctor when my own supply of DMPS ran out) and when at the doctor he has been including ALA (first ALA, then DMPS i.v.) since year #2 of my treatment. i.v. is just much more "powerful" - but I can readily see why people who do too much of it suffer (some doctors - in Germany mostly? - only know DMPS i.v. so that's all they use, I heard from patients getting DMPS i.v. every two weeks and that didn't go so well for them).