A close friend quickly gained over 10lbs when she started on hydrocortisone for her adrenal fatigue. She has done much better on pregnenolone plus just a tiny dose of HC and other adrenal related supplements.
"Estrogen dominant" usually refers to imbalance of E and progesterone. Pregnenolone is the immediate precursor to prog. However since it is an inexpensive supplement, don't expect your doc to mention it ; ) http://en.wikipedia.org/wiki/File:Steroidogenesis.svg