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Albendazole's mechanism of action
 
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Published: 10 y
 

Albendazole's mechanism of action


Most mainstream reliable sources of info (wikipedia, mayoclinic, webmd, etc) state that Albendazole works by damaging the worms' ability to create and use ATP/glucose. I think this is wrong diction. I think instead of "damage", the word used should be "restrict".

This is because about 8-12 hours after taking the drug, i can feel the crawlies again in my whole body. Therefore, the drug must have a temporary effect that causes the worms to become immobile hours after taking the drug. However, once the drug has worn off, the worms go back to their previous state. This is not damage, which implies that something has been caused to the organism so that it can no longer perform a task as well or at all. But the worms go back to their previous state after 8-12 hours, so i think that the drug works by restricting the worm's ability to use ATP and therefore to move.

If this is true that albendazole only restricts instead of damage, the only way to get it to kill worms is to NEVER let the drug wear off completely. Since there is no damage that is accumulated, and the drug works by starving the worm to gradual death, we cannot let the worm regain ability to use ATP, which undoes the starving we are trying to do to it.

Any thoughts on this? Please correct me if my theory is incorrect and if albendazole does indeed damage worms instead of just temporarily restrict their ability to use ATP.
 

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