Bloating, brain fog, fatigue, terrible digestion and food allergies are my main issues. I'd recommend urine therapy for anyone though. What I notice with urine therapy is it definitely causes die off when I use it by itself. At the moment I'm doing it with a bunch of other therapies. If you need to get rid of the die off sparingly use coffee enemas. If you have candida issues, you likely have adrenal issues, so thus sparingly, unless for a specific cleanse.