Expevct to have to take Lugols for months not days or weeks to really benefit.
As for the feeling you get from cofactors, thats likely an indication you are deficient on one or more B's as well.
Vit C is a powerful natural antioxidant and powerful antihistamine so can work wonders in helping with toxicity. Peoples biggest problem with vit C is not taking enough, id shoot for 6 grams a day minimum, ideally as much as you can tolerate without watery stools.