For me it's highly associated to my ovarian cyst. The chinese have an interesting Science that they rely on called physiognomy, where they can tell what organs/systems are affected, by the qualities of the different areas of your face. My flare ups tend to happen on my lower right chin area, which represents the large intestine and sexual organs. No surprise that I have a large (basketball sized!) ovarian cyst, and my colon has been disrupted partially by that, and partially from my lack of hydration (not drinking enough water, and too much coffee can dry out your stool, thereby giving you constipation). I also get some pimples occasionally on my cheeks. Apparently the cheeks represent the heart and lungs...no surprise because of my sensitivity to dairy. When I eat dairy products, I get asthma.
I would say drink lots of water each day (2 liters, at least) and cleanse your body. Check yourself out for food sensitivities . This will help you to avoid those foods that stress your system.