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Re: Help, I suffer from Nitrosative Stress and Oxidative Stress
 
tom3tom Views: 9,259
Published: 11 y
 
This is a reply to # 2,172,555

Re: Help, I suffer from Nitrosative Stress and Oxidative Stress


I can't find a specific reference to the acid you mentioned, but here's a superb article that looks to encompass exactly what you describe. your nitrosative stress is surely originating in the NO-/ONOO- Cycle.

your symptoms will also match many listed under the deficiency symptoms & diseases.

Short answer is it looks to be the specific hydroxycobalamin B12 (1 of the 4 supplement forms of B12)which can quench the NO- & break the destructive positive regeneration loop of the NO-/ONOO- Cycle:
http://www.immunesupport.com/shop/images/article_8749_CFIDS_FM_sm.gif

have u tried or are you taking a good high dose hydroxy (also spelled 'hydroxo-') B12? It is available under many manufacturers, & for instance amazon.com sells many brands.
it comes in a 1000 ug or 2000 ug sublingual lozenge, about $15- $25 for 1 BT 60 to 100.

unfortunately, the key book on this by the theory's founder Dr. Pall, published in 2007, costs $75 so no one can buy it, or has read it apparently!
http://astore.amazon.com/prohealth-20/detail/078902389X/104-0633642-5692763

Hydroxocobalamin Breaks the NO-/ONOO- Cycle

Hydroxocobalamin (cobinamide), a unique form of vitamin B-12, is a potent nitric oxide (NO-) scavenger. It is the only form of vitamin B-12 that effectively neutralizes the NO- molecule. Hydroxocobalamin is the preferred form of vitamin B-12 required to break the NO-/ONOO- vicious cycle of cellular damage.

The Methylation Cycle and ME/CFS

The methylation cycle is a biochemical pathway required for the manufacture of DNA, RNA, phospholipids (myelin sheath of nerves), neurotransmitters, adrenal hormones and more than 100 enzymes. A fully functional methylation cycle is also required for numerous detoxification reactions.

http://www.prohealth.com//library/showArticle.cfm?libid=13595
 

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