Thanks so much for your info,I use the cream as I tested low in saliva tests, high estrogen, breast cycts ect it has worked wonderfully, I am much worse in my first 2 weeks and much better in the last 2 so my thinking is that if the progesterone was used to make more cortisol wouldn't I be worse in the last 2 weeks? I am no longer under the stress but it was intense for a few years, constant,I really think I haven't fully got over that so I am working on that as well.