I don't have a quote from Andy on this but I suspect it is based on probabilities. You want to increase the odds that Hg dropped by a molecule of chelator will get picked up by another molecule of it. You don't want the mobilized/kicked up Hg causing additional oxidation damage or finding one of the parts of the body that holds on rather tightly.
In the beginning some people are too sick to be able to tolerate much of the sfx of mobilizing Hg. So they are stuck with very low doses for a while. Once enough Hg is cleared from the blood, and they find a nice combo of supporting supplements, sometimes some medication, they should be able to tolerate more generous doses. Those doses are likely to produce only minor-moderate sfx while on round.