Re: problem with my DNA in relation to skin adhesion

I ordered a ($99) DNA ancestry kit from ancestry.com, then uploaded my raw DNA file to promethease.com for a limited DNA health analysis ($5). You have to wait a few weeks to receive the results of your DNA test from ancestory.com before you can upload your raw DNA file to promethease.com. Or you can have a genetics counselor prescribe this test. Since I do not think health insurance covers DNA tests, the ancestry/promethease option is probably cheaper.

Also, "As basal cells reproduce and mature, they move towards the outer layer of skin, initially forming the stratum spinosum. Intercellular bridges, the DESMOSOMES, which appear as `prickles' at a microscopic level, connect the cells."

"The main cells of the epidermis are the keratinocytes, which synthesise the protein keratin. Protein bridges called DESMOSOMES connect the keratinocytes."

"Shedding the cells of the stratum corneum is an important factor in maintaining skin integrity and smoothness. Desquamation involves the enzymatic process of dissolving the protein bridges, the DESMOSOMES, between the corneocytes, and the eventual shedding of these cells.The proteolytic enzymes responsible for desquamation are located intracellularly and function in the presence of a well-hydrated stratum corneum. In the absence of water the cells do not desquamate normally and the skin becomes roughened, dry, thickened and scaly. In normal healthy skin, there is a balance in the production and shedding of corneocytes. In diseases such as psoriasis, which involve increased corneocyte production, and where decreases in shedding occur, the result is dry, rough skin as the cells accumulate on the skin."

http://europepmc.org/abstract/MED/10379701/reload=0;jsessionid=5ZcYw9ffBNJD9q...


Tweet