Re: Kangen (Alkaline) Water Myths and Hype

Wow, I wasn't surprised when Dr. Mercola did a propaganda piece on Ionized Water without bothering to research the topic, but I'm stunned to see a website that I had respected and in fact have referred others to many times - curezone - do the same thing.

There are so many mistakes in your post I don't even know where to begin.

Yes some distributors make mistakes when describing chemistry, but that does NOT negate the abundant medical research on the alkaline drinking water (NOT just the acidic water used topically, as you imply) which I would be happy to email to anyone who asks.

Here are just a few examples, among many:
Electrolyzed-reduced water protects against oxidative damage to DNA, RNA, and protein.
Lee MY, Kim YK, Ryoo KK, Lee YB, Park EJ.
Department of Genetic Engineering, Soonchunhyang University, Asan, Chungnam 336-600, Korea. miyoung@sch.ac.kr
The generation of reactive oxygen species is thought to cause extensive oxidative damage to various biomolecules such as DNA, RNA, and protein. In this study, the preventive, suppressive, and protective effects of in vitro supplementation with electrolyzed-reduced water on H2O2-induced DNA damage in human lymphocytes were examined using a comet assay. Pretreatment, cotreatment, and posttreatment with electrolyzed-reduced water enhanced human lymphocyte resistance to the DNA strand breaks induced by H2O2 (Hydrogen-Peroxid) in vitro. Moreover, electrolyzed-reduced water was much more effective than diethylpyrocarbonate-treated water in preventing total RNA degradation at 4 and 25 degrees C. In addition, electrolyzed-reduced water completely prevented the oxidative cleavage of horseradish peroxidase, as determined using sodium dodecyl sulfate-polyacrylamide gels. Enhancement of the antioxidant activity of ascorbic acid dissolved in electrolyzed-reduced water was about threefold that of ascorbic acid dissolved in nonelectrolyzed de Ionized Water , as measured by a xanthine-xanthine oxidase superoxide scavenging assay system, suggesting an inhibitory effect of electrolyzedreduced water on the oxidation of ascorbic acid.
PMID: 17159237 [PubMed - indexed for MEDLINE]
-------------------------------------------------
Electrolyzed-reduced water scavenges active oxygen species and protects DNA from oxidative damage.
Shirahata S, Kabayama S, Nakano M, Miura T, Kusumoto K, Gotoh M, Hayashi H, Otsubo K, Morisawa S, Katakura Y.
Institute of Cellular Regulation Technology, Graduate School of Genetic Resources Technology, Kyushu University, Fukuoka, Japan. sirahata@grt.kyushu-u.ac.jp
Active oxygen species or free radicals are considered to cause extensive oxidative damage to biological macromolecules, which brings about a variety of diseases as well as aging. The ideal scavenger for active oxygen should be 'active hydrogen'. 'Active hydrogen' can be produced in reduced water near the cathode during electrolysis of water. Reduced water exhibits high pH, low dissolved oxygen (DO), extremely high dissolved molecular hydrogen (DH), and extremely negative redox potential (RP) values. Strongly electrolyzed-reduced water, as well as ascorbic acid, (+)-catechin and tannic acid, completely scavenged O.-2 produced by the hypoxanthine-xanthine oxidase (HX-XOD) system in sodium phosphate buffer (pH 7.0). The superoxide dismutase (SOD)-like activity of reduced water is stable at 4 degrees C for over a month and was not lost even after neutralization, repeated freezing and melting, deflation with sonication, vigorous mixing, boiling, repeated filtration, or closed autoclaving, but was lost by opened autoclaving or by closed autoclaving in the presence of tungsten trioxide which efficiently adsorbs active atomic hydrogen. Water bubbled with hydrogen gas exhibited low DO, extremely high DH and extremely low RP values, as does reduced water, but it has no SOD-like activity. These results suggest that the SOD-like activity of reduced water is not due to the dissolved molecular hydrogen but due to the dissolved atomic hydrogen (active hydrogen). Although SOD accumulated H2O2 (Hydrogen-Peroxid) when added to the HX-XOD system, reduced water decreased the amount of H2O2 (Hydrogen-Peroxid) produced by XOD. Reduced water, as well as catalase and ascorbic acid, could directly scavenge H2O2. Reduce water suppresses single-strand breakage of DNA b active oxygen species produced by the Cu(II)-catalyzed oxidation of ascorbic acid in a dose-dependent manner, suggesting that reduced water can scavenge not only O2.- and H2O2, but also 1O2 and .OH.
PMID: 9169001 [PubMed - indexed for MEDLINE]
---------------------------------------------------
Prof. Kogure Keizou, Kogure Clinic of Juntendo Hospital
"The stomach is readily upset both by diseases affecting the stomach and by other general illnesses. In addition, any nervous tension or anxiety frequently causes gastric upset, vague symptoms when This information is under some strain.
The important role of antioxidant water in our stomach is to neutralize the secretion and strengthen its functions. Usually, after consuming the antioxidant water for 1 to 3 minutes, the gastric juice increase to 1½ times. For those suffering from hypochlorhydria or achlorhydria ( low in gastric juice ) the presence of antioxidant water will stimulate the stomach cells to secrete more gastric juice. This in turn enhances digestion and absorption of minerals.
However, on the other hand, those with hyperchlorhydria ( high in gastric juice ), the antioxidant water neutralizes the excessive gastric juice. Hence, it does not create any adverse reaction.
According to the medical lecturer from Maeba University, the pH of the gastric secretion will still remain normal when antioxidant water is consumed. This proves that the ability of the antioxidant water is able to neutralize as well as to stimulate the secretion."
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Inhibiting effect of functional water on formation of fatty acid peroxides
Electrolyzed reduced water was found to inhibit formation of fatty acid peroxides, and antiarteriosclerotic effects are anticipated.
Japan Society for Bioscience, Biotechnology, and Agrochemistry (Sendai)
Yoko Sugihara et al
2002
Protective effect of reduced water against alloxan induced damage to pancreatic ?-cells
Reduced water was found to inhibit damage to pancreatic ?-cells caused by alloxan, which triggers type-1 diabetes, and to promote insulin secretion.
Japan Society for Bioscience, Biotechnology, and Agrochemistry (Sendai)
Makoto Kaminishi et al
2002
Suppressive effect of electrolyzed reduced water on nerve cell death caused by oxidative stress
Electrolyzed reduced water was found to suppress nerve cell death caused by oxidative stress.
Japan Society for Bioscience, Biotechnology, and Agrochemistry (Sendai)
Taichi Kashiwagi et al
2002
Suppressive effect of electrolyzed reduced water on multiplication of human leukemia cells
Electrolyzed reduced water was found to inhibit multiplication of human leukemia cells and to induce differentiation into normal cells.
Japan Society for Bioscience, Biotechnology, and Agrochemistry (Sendai)
Takaaki Komatsu et al
2002
Suppression of lipid peroxidation by electrolyzed reduced water
Electrolyzed reduced water was found to inhibit peroxidation of linoleic acid and cellular membranes.
15th meeting of JAACT, Tokyo
Takeki Hamasaki et al
2002
Electrolyzed reduced water induces differentiation in K562 human leukemia cells.
Electrolyzed reduced water was found to induce megakaryocytic differentiation in human leukemia cells.
15th meeting of JAACT, Tokyo
Takaaki Komatsu et al
2002
Suppression of glutamate-induced neural death of PC12 cells by electrolyzed reduced water
Electrolyzed reduced water was found to inhibit glutamate-induced death of PC12 nerve cells.
15th meeting of JAACT, Tokyo
Taichi Kashiwagi et al
2002
Protective action of reduced water against alloxan-induced cytotoxicity in pancreatic ?-cell
Reduced water was found to provide protection against alloxan-induced cytotoxicity in pancreatic ?-cells.
15th meeting of JAACT, Tokyo
Yuping Li et al
2002
Protective mechanism of reduced water against alloxan-induced pancreatic ?-cell damage: Scavenging effect against reactive oxygen species
By eliminating active oxygen, reduced water was found to provide protection against pancreatic ?-cell damage due to alloxan toxicity.
Cytotechnology, 40, 139–149
Yuping Li et al
2002
Phenotypic changes in tumor cells induced by electrolyzed reduced water
Electrolyzed reduced water was found to inhibit the formation of malignant phenotype colonies by tumor cells
Japan Society for Bioscience, Biotechnology, and Agrochemistry, Joint Conference of Kansai, West Japan, Chugoku, and Shikoku Chapters
Hirofumi Nogami et al
2001
Antidiabetic effectiveness of electrolyzed reduced water and natural reduced water
Both electrolyzed reduced water and natural reduced water were found to promote Sugar uptake into muscle tissue and to improve glucose tolerance disorders in model mice with type-2 diabetes.
Japan Society for Bioscience, Biotechnology, and Agrochemistry, Joint Conference of Kansai, West Japan, Chugoku, and Shikoku Chapters
Makoto Kaminishi et al
2001
“Phenotypic changes in tumor cells induced by electrolyzed reduced water”
Electrolyzed reduced water was found to inhibit metastasis and infiltration of cancer cells.
Japanese Association for Animal Cell Technology (Kyoto)
Hirofumi Nogami et al
2001
Suppressive effect of electrolyzed-reduced water on the growth of cancer cells and microorganisms
Electrolyzed reduced water was found to inhibit the proliferation of cancer cells and microorganisms.
17th ESACT Meeting (Sweden)
S. Shirahata et al
2001
Anti-oxidative water improves diabetes
Provides a comprehensive explanation of the effectiveness of anti-oxidative water in improving diabetes.
17th ESACT Meeting (Sweden)
S. Shirahata et al
2001
Study of cancer-inhibiting effects of electrolyzed reduced water
Using electrolyzed reduced water to suppress the secretion of proteolytic enzymes by cancer cells was found to inhibit metastasis and infiltration of cancer cells.
Japan Society for Bioscience, Biotechnology, and Agrochemistry
Taichi Hara et al
2000
Inhibition of cancerous characteristics by reduced water
Electrolyzed reduced water was found to inhibit characteristics associated with metastasis and infiltration of cancer cells.
Japanese Tissue Culture Association (Okayama)
Kiichiro Teruya et al
2000
Study of cancer-inhibiting effects of electrolyzed reduced water
Electrolyzed reduced water was found to inhibit metastasis and infiltration of cancer cells.
Japan Society for Bioscience, Biotechnology, and Agrochemistry
Taichi Hara et al
1999
Effects of electrolyzed reduced water on Sugar uptake signal pathways
Electrolyzed reduced water was found to inhibit the growth of cancer cells and to induce phenotypical changes.
Japan Society for Bioscience, Biotechnology, and Agrochemistry
Masaaki Oda et al
1999
Electrolyzed and natural reduced water exhibit insulin-like activity on glucose uptake into muscle cells and adipocytes
Electrolyzed reduced water was found to promote glucose uptake into muscle cells and adipocytes in a manner similar to insulin.
The 16th meeting of the European Society for Animal Cell Technology
S. Shirahata et al
1999
Effects of electrolyzed reduced water in eliminating active oxygen and protecting against oxidative damage to DNA
Electrolyzed reduced water was found to eliminate superoxide radicals produced in a test tube. It also suppressed DNA damage caused by active oxygen.
Japan Society for Bioscience, Biotechnology, and Agrochemistry
Masaaki Oda et al
1998
Effects of electrolyzed reduced water in inhibiting proliferation of cancer cells
Electrolyzed reduced water was found to inhibit proliferation of cancer cells and to induce phenotypical changes.
Japan Society for Bioscience, Biotechnology, and Agrochemistry
Eri Murakami et al
1998
Telomere shortening in cancer cells by reduced water.
Electrolyzed reduced water was found to induce telomere shortening and deterioration in cancer cells.
The joint international meeting of the Japanese Association for Animal Cell Technology (JAACT) and the European Society for Animal Cell Technology (ESACT)
S. Shirahata et al
1998
Electrolyzed-reduced water scavenges active oxygen species and protects DNA from oxidative damage.
Electrolyzed reduced water was found to eliminate superoxide radicals produced in a test tube. It also suppressed DNA damage caused by active oxygen.
Biochemical and Biophysical Research Communications, 234, 269-274
S. Shirahata et al
1997
Antioxidative effect of electrolyzed-reduced water supplemented with platinum nanoparticle and effects on parkinson model animal 
The 4th meeting of the Japanese Soiety for Functional Water (Hakodate) 
Akitami Sato et al
2005
Diabetes prevention through redox regulation by reduced water
The 4th meeting of the Japanese Soiety for Functional Water (Hakodate) 
Sanetaka Shirahata et al
2005
Redox regulation and diabetes prevention by reduced water
Japanese Association for Animal Cell Technology  (Tokyo) , The joint meeting of west Japan and Hokkaido of Japan Society for Bioscience, Biotechnology, and Agrochemistry  (Fukuoka)  
Kiichiro Teruya et al
2005
Redox regulation by reduced waters as active hydrogen donors and intracellular ROS scavengers for prevension of diabetes
The 19th European Society for Animal Cell Technology Meeting (Harrogate, UK)
S. Shirahata et al
2005
Induction of caspase-3-dependent apoptosis by electrolyzed reduced water/platimum nanoparticels in cancer cells
The 19th European Society for Animal Cell Technology Meeting (Harrogate, UK)
T. Hamasaki et al
2005
Analysis of superoxide anion and hydroxyl radical scavenging activities by platinum nanoparticle
Japan Society for Bioscience, Biotechnology, and Agrochemistry (Sapporo)
Takeki Hamasaki et al
2005
Suppressive effect of reduced water with reactive oxygen species scavenging activity on type 1 diabetes mellitus
Japan Society for Bioscience, Biotechnology, and Agrochemistry (Sapporo)
Yuping Li et al
2005
Electrolyzed reduced water supplemented with platinum nanoparticles suppresses promotion of two-stage cell transformation
Cytotechnology
R. Nishikawa et al
2005
Analysis of hydroxyl radical scavenging activity by platinum nanoparticle
The 3rd meeting of the Japanese Soiety for Functional Water (Tokyo) 
Takeki Hamasaki et al
2004
Medical application of reduced water as reactive oxygen species scavenger and active hydrogen donor
The 17th Annual Meeting of the Japanese Association for Animal Cell Technology(Nagoya)
S. Shirahata
2004
Platimum nanoparticels in electrolyzed reduced water induces apoptosis in cancer cells
The 17th Annual Meeting of the Japanese Association for Animal Cell Technology(Nagoya)
T. Hamasaki et al
2004
Suppression of two-stage cell transformation by electrolyzed reduced water/platinum nanocolloids
The 17th Annual Meeting of the Japanese Association for Animal Cell Technology(Nagoya)
R. Nishikawa et al
2004
Suppression of Invasion of Cancer Cells and Angiogenesis by Electrolyzed Reduced Water
2004 World Congress on In Vitro Biology(USA)
Y. Jun et al
2004
Suppression of Two-stage Cell Transformation by Electrolyzed Reduced Water/Platinum Nanocolloids
2004 World Congress on In Vitro Biology(USA)
R. Nishikawa et al
2004
Mechanism for suppressive effect of reduced water with reactive oxygen species scavenging activity on diabetes
Japan Society for Bioscience, Biotechnology, and Agrochemistry (Hiroshima) 
Yuping Li et al
2004
Suppression of apoptosis by reduced water in nerve cells
Japan Society for Bioscience, Biotechnology, and Agrochemistry (Hiroshima) 
Tenyou Ishikawa et al
2004
Effect of reduction of platinum nanocolloids and electrolyzed-reduced water on nerve cells
Japan Society for Bioscience, Biotechnology, and Agrochemistry (Hiroshima) 
Taichi Kashiwagi et al
2004
Induction of cancer cell-specific apoptosis by electrolyzed-reduced water/platinum nanoparticels
Japan Society for Bioscience, Biotechnology, and Agrochemistry (Hiroshima)
Shinsuke Aramaki et al
2004
Reaction kinetics analysis of reactive oxygen species scavenging activity of platinum nanocolloids
Japan Society for Bioscience, Biotechnology, and Agrochemistry (Hiroshima) 
Takeki Hamasaki et al
2004
Reduced water functions as active hydrogen donors and  ROS scavengers
Japan Society for Bioscience, Biotechnology, and Agrochemistry (Hiroshima)  
Sanetaka Shirahata et al
2004
Suppression of carcinogenesis mutation formation at promortion stage by electrolyzed-reduced water /platinum nanocolloid
Japan Society for Bioscience, Biotechnology, and Agrochemistry (Hiroshima)  
Ryuhei Nishikawa et al
2004
Characteristic analysis of  reduced waters as active hydrogen donors and reactive oxygen species  scavenger
The 2nd meeting of the Japanese Soiety for Functional Water (Gifu) 
Sanetaka Shirahata et al
2003
Characteristic analysis of  platinum nanocolloids as active hydrogen donors and reactive oxygen species  scavenger
The 2nd meeting of the Japanese Soiety for Functional Water (Gifu) 
Takeki Hamasaki et al
2003
Suppressive effect of reduced water against alloxan induced type 1 diabetes mellitus
The 2nd meeting of the Japanese Soiety for Functional Water (Gifu) 
Yuping Li et al
2003
Effects of Electrolyzed-Reduced Water on the Matrix Metalloproteinase-2 Activities and In Vitro Invasion of Human Fibrosarcoma HT1080 Cells
The 2nd meeting of the Japanese Soiety for Functional Water (Gifu) 
J. Ye et al
2003
Induction of apoptosis by platinum nanocolloids/electrolyzed reduced water in cancer cells
The 2nd meeting of the Japanese Soiety for Functional Water (Gifu) 
Shinsuke Aramaki et al
2003
Electrolyzed-reduced water protects nerve cells from glutamic acid toxicity 
The 2nd meeting of the Japanese Soiety for Functional Water (Gifu) 
Taichi Kashiwagi et al
2003
Suppression of apoptosis by reduced water in nerve cells
The 2nd meeting of the Japanese Soiety for Functional Water (Gifu) 
Tenyou Ishikawa et al
2003
Suppression of two-stage carcinogenic focus formation by electrolyzed-reduced water/ platinum nanocolloids
The 2nd meeting of the Japanese Soiety for Functional Water (Gifu) 
Ryuhei Nishikawa et al
2003
Function analysis of platinum nanocolloids as active hydrogen donors and reactive oxygen species  scavenger
The joint meeting of West Japan and Cyugoku?Sikoku of Japan Society for Bioscience, Biotechnology, and Agrochemistry ,West Japan of Japanese Society of Nutrition and Food Science,West Japan of The Japanese Society for Food Science and Technology (Kagoshima)
Toshifumi Imada et al
2003
Suppressive effect of electrolyzed-reduced water/platinum nanocolloids on proliferation of  cancer cells
The joint meeting of West Japan and Cyugoku?Sikoku of Japan Society for Bioscience, Biotechnology, and Agrochemistry ,West Japan of Japanese Society of Nutrition and Food Science,West Japan of The Japanese Society for Food Science and Technology (Kagoshima)
Shinsuke Aramaki et al
2003
Suppression of  carcinogenic focus formation by electrolyzed-reduced water/platinum nanocolloids
Japanese Association for Animal Cell Technology  (Osaka)
Ryuhei Nishikawa et al
2003
Suppressive effect of electrolyzed-reduced water against  nerve cell death induced by oxidative stress
Japanese Association for Animal Cell Technology  (Osaka)
Taichi Kashiwagi et al
2003
Scavenging of reactive oxygen species and suppressive effect on cell growth by hydrogen-platinum nano colloids 
Japanese Association for Animal Cell Technology  (Osaka)
Takeki Hamasaki et al
2003
Suppressive effect of reduced water on pancreatic ?-cells damage caused by oxidative stress 
Japanese Society of Nutrition and Food Science (Fukuoka)
Yuping Li et al
2003
Suppressive effect of reduced water on the apoptotic cell death triggered by oxidative stress in pancreatic ? HIT-T15 cells
18th ESACT Meetings(Spain)
S. Shirahata et al
2003
Physiological functions of platinum nanocolloides as scavengers against reactive oxygen species
18th ESACT Meetings(Spain)
T. Hamasaki et al
2003
The inhibition of VEGF expression in human fibrosarcoma HT 1080 cells by electrolyzed-reduced water
Japan Society for Bioscience, Biotechnology, and Agrochemistry (Kanagawa)
June Ye et al
2003
Effectiveness of platinum nanocolloid in eliminating active oxygen
Japan Society for Bioscience, Biotechnology, and Agrochemistry (Kanagawa)
Takeki Hamasaki et al
2003
Suppressive effect of  electrolyzed-reduced water on glutamic acid induced nerve cytotoxicity
Japan Society for Bioscience, Biotechnology, and Agrochemistry (Kanagawa)
Taichi Kashiwagi et al
2003
Suppressive effect of reduced water on the apoptotic cell death triggered by oxidative stress in pancreatic ?-cells
Japan Society for Bioscience, Biotechnology, and Agrochemistry (Kanagawa)
Yuping Li et al
2003
Analysis of mechanisim for differentiation induceded by electrolyzed- reduced water in  K562 human leukemia cells
Japan Society for Bioscience, Biotechnology, and Agrochemistry (Kanagawa)
Takaaki Komatsu et al
2003
The inhibition of VEGF expression in human fibrosarcoma HT1080 cells by electrolyzed-reduced water
Japan Society for Bioscience, Biotechnology, and Agrochemistry (Tokyo)
June Ye et al
2003
Effectiveness of platinum nanocolloid in eliminating active oxygen
Japan Society for Bioscience, Biotechnology, and Agrochemistry (Tokyo)
Takeki Hamasaki et al
2003
Inhibition of glutamic acid neuron toxicity by electrolyzed reduced water
Japan Society for Bioscience, Biotechnology, and Agrochemistry (Tokyo)
Taichi Kashiwagi et al
2003
Suppressive effect of reduced water on the apoptotic cell death triggered by oxidative stress in pancreatic ?-cells
Japan Society for Bioscience, Biotechnology, and Agrochemistry (Tokyo)
Yuping Li et al
2003
Analysis of electrolyzed reduced water as a differentiation inducing mechanism for K562 human leukemia cells
Japan Society for Bioscience, Biotechnology, and Agrochemistry (Tokyo)
Takaaki Komatsu et al
2003
The inhibition of VEGF expression in human fibrosarcoma HT1080 cells by electrolyzed-reduced water
Japan Society for Bioscience, Biotechnology, and Agrochemistry (Tokyo)
June Ye et al
2003
Effectiveness of platinum nanocolloid in eliminating active oxygen
Japan Society for Bioscience, Biotechnology, and Agrochemistry (Tokyo)
Takeki Hamasaki et al
2003
Inhibition of glutamic acid neuron toxicity by electrolyzed reduced water
Japan Society for Bioscience, Biotechnology, and Agrochemistry (Tokyo)
Taichi Kashiwagi et al
2003
Suppressive effect of reduced water on the apoptotic cell death triggered by oxidative stress in pancreatic ?-cells
Japan Society for Bioscience, Biotechnology, and Agrochemistry (Tokyo)
Yuping Li et al
2003
Analysis of electrolyzed reduced water as a differentiation inducing mechanism for K562 human leukemia cells
Japan Society for Bioscience, Biotechnology, and Agrochemistry (Tokyo)
Takaaki Komatsu et al
2003


Title
Conference, Collaborators
Year
Suppressive effect of electrolyzed reduced water on angiogenesis and invasion of tumor cells.
The 66th Annual Meeting of the Japanese Cancer Association 
S. Shirahata
2007
Research on anti-Parkinson's disease effect by functional food and functional water
The 61st annual meeting of Kyushu?Okinawa of Japanese Society of Nutrition and Food Science
T.Abiru et.al
2007
Research on functional water and functional food with anti-Parkinson's disease
The joint meeting of West Japan and Cyugoku?Sikoku of Japan Society for Bioscience, Biotechnology, and Agrochemistry 2007
T.Abiru et.al
2007
Action mechanism of reduced water for prevention and improvement of oxidative stress-related diseases.
Invited seminar in Karolinska Institute (Stockholm, Sweden)
S. Shirahata
2007
Development of less oxidative hemodialysis solution and it's effect on neutrophil
The 52th Annual Meeting of the Japanese Society for Dialysis Therapy
Masaaki Nakayama et.al.
2007
Effect of Electrolyzed cathodic water (EW) on kidney injury of Dahl salt sensitive rat (DS)
The 50th Annual Meeting of Japanese Society of Nephrology
Wan-Jun Zhu et.al.
2007
Less-oxidative hemodialysis solution rendered by cathode-side application of electrolyzed water
Hemodialysis International 2007; 11:322-327
Masaaki Nakayama et al.,
2007
Protective effects of platinum nanoparticles against cellular dysfunction by superoxide anion radical in HeLa cells.
Annual meeting of Japan Society for Bioscience, Biotechnology, and Agrochemistry 
Takeki Hamasaki et al.,
2007
Anti atheloscrelosis effects of Electrolyzed-reduced water.
Annual meeting of Japan Society for Bioscience, 
Biotechnology, and Agrochemistry
Masumi Abe et al.,
2007
Evaluation of oxidant and antioxidant activities of various potable waters by ESR.
Annual meeting of Japan Society for Bioscience, 
Biotechnology, and Agrochemistry 
Kazuko Toh et al.,
2007
Mechanism and function of drinking alkaline electrolyzed water.
The 5th meeting of Japanese society for functional 
water (Miyagi Zao)
Sanetaka Shirahata et al.,
2006
Protective effects of platinum nanoparticles against cellular dysfunction by Reactive Oxygen Species.
The 5th meeting of Japanese society for functional
water (Miyagi Zao)
Takeki Hamasaki et al.,
2006
Scavenging activities of superoxide radicals by platinum nanoparticles.
Annual Meeting of the Society of Electron Spin 
Science and Technology (Kyoto)
Takeki Hamasaki et al.,
2006
Evaluation of oxidant and antioxidant activities of various potable waters by ESR.
Annual Meeting of the Society of Electron Spin 
Science and Technology (Kyoto) 
Kazuko Toh et al.,
2006
Platinum nanoparticles protect HeLa cells from ROS damage.
The 19th International Meeting of Japanese Association for Animal Cell Technology (Kyoto)
Takeki Hamasaki et al.,
2006
Nordenau phenomenon-application of natural reduced water to therapy. 
Follow up study upon 411 diabetes patients.
The 19th International Meeting of Japanese 
Association for Animal Cell Technology (Kyoto)
Z. Gadek et al.,
2006
Action mechanisms of reduced water for prevention of oxidative stress-related diseases.
The satellite symposium of JAACT2006 Kyoto
(Fukuoka city) 
Shirahata, S
2006
Application of water to medical care, fact and clinical application of study of reduced water.
The Animal Cell Technology symposium of JAACT 
2006 (Tokyo)
Shirahata Sanetaka
2006
Antioxidant activities and effects to Parkinson's disease model animals of platinum 
nanoparticles and electrolyzed-reduced water supplemented with platinum nanoparticles.
Annual meeting of Japan Society for Bioscience, 
Biotechnology, and Agrochemistry 2006
Eliko Takahashi et al.,
2006


Redox regulation by model water for electrolyzed-reduced water
The 8th Annual Meeting of the Japanese society for functional water 
Ayumi Hosokawa et.al.
2009
Analysis of nano particle on biological availability and toxicity
The 8th Annual Meeting of the Japanese society for functional water
Keishi Kadooka et.al.
2009
Survival benefit of electrolyzed-reduced water on nematode
The 8th Annual Meeting of the Japanese society for functional water
H. Yan et.al.
2009
Analysis of inducible mechanism of cancer cell death by atomic hydrogen
The 8th Annual Meeting of the Japanese society for functional water
Katsuhiko Shigiyama et.al.
2009
Examination of anti-diabetic effect of model water for electrolyzed-reduced water
The 8th Annual Meeting of the Japanese society for functional water
Takuro Nakamura et.al.
2009
Suppressive effect of Electrolyzed Water with high dissolved Hydrogen (H2) on Cardiorenal syndrome of Dahl Salt sensitive rat
Renal Week 2009, American Society of Nephrology?
Wan-Jun Zhu et.al.
2009
Induction of apoptosis of cancer cells by atomic hydrogen produced by catalyst activity of platinum nanoparticles
The 68th Annual Meeting of the Japanese Cancer Association
Sanetaka Shirahata et.al.
2009
Use experience of electrolysis hemodialysis using electrolyzed-reduced water
The joint meeting of the 76th Annual Meeting of theHokkaido Dialysis Therapy and the 36th Scientific Meeting of the Tohoku renal failure 
Susumu Uemura et.al.
2009
Clinical evaluation of hemodialysis using electrolyzed-reduced water
The 54th Annual Meeting of the Japanese Society for Dialysis Therapy (Japan Kidney Week 2009)
Koichi Ishibashiri et.al.
2009
Case report of a patient accepted reduction of itch by dialysate using electrolyzed-reduced water
The 54th Annual Meeting of the Japanese Society for Dialysis Therapy (Japan Kidney Week 2009)
Ryoichi Nakazawa et.al.
2009
Examination of hemodialysis system using electrolyzed water
The 54th Annual Meeting of the Japanese Society for Dialysis Therapy (Japan Kidney Week 2009)
Hiroshi Nemoto et.al.
2009
Use experience of electrolysis hemodialysis using water at cathod side of electrolysis
The 54th Annual Meeting of the Japanese Society for Dialysis Therapy (Japan Kidney Week 2009)
Susumu Uemura et.al.
2009
Effect of Electrolyzed-reduced water on skin temperature of lower limb on hemodialysis patients
The 54th Annual Meeting of the Japanese Society for Dialysis Therapy (Japan Kidney Week 2009)
Akiko Kobayashi et.al.
2009
Evaluation of water from hemodialysis system by using electrolyzed-reduced water
The 54th Annual Meeting of the Japanese Society for Dialysis Therapy (Japan Kidney Week 2009)
Minako Yataka et.al.
2009
Exploratory investigation about long-term clinical effect of electrolysis hemodialysis
The 54th Annual Meeting of the Japanese Society for Dialysis Therapy (Japan Kidney Week 2009)
Masaaki Nakayama et.al.
2009
Examination of intake of electrolyzed water on supressive effect of kidney injury in cronic kidney disease (CKD) model rat
The 52nd Annual Meeting of Japanese Society of Nephrology
Wan-Jun Zhu et.al.
2009
Fundamental investigation for supressive effect of intake of electrolyzed water on cardiorenal organ dysfunction
The 8th Scientific Meeting of the Japanese Society of Anti-Aging Medicine
Wan-Jun Zhu et.al.
2009
Biological effect of Electrolyzed Water in Hemodialysis
Nephron Clinical Practice 2009;112:c9–c15 
Masaaki Nakayama et.al.
2009
Induction mechanism of cell death of cancer cells by atomic hydrogen
Annual Meeting of Japan Society for Bioscience, Biotechnology, and Agrochemistry 2009
Katsuhiko Shigiyama et.al.
2009
Anti-diabetes effects of electrolyzed reduced water and its model water
Annual Meeting of Japan Society for Bioscience, Biotechnology, and Agrochemistry 2009
Takuro Nakamura et.al.
2009
Redox regulation by electrolyzed reduced water and its model water
Annual Meeting of Japan Society for Bioscience, Biotechnology, and Agrochemistry 2009
Ayumi Hosokawa et.al.
2009
Next-generation hemodialysis system for palliating lassitude after hemodaialysis
The 6th Japan Congress Support of Home Dialysis
Masaaki Nakayama et.al.
2009
Electrolyzed water at cathode side (EW) suppressed renal injury in chronic kidney disease rats
The 9th Scientific Meeting of renal failure pathosis therapy
Wan-Jun Zhu et.al.
2008
Collaboration for clinical effect of electrolysis hemodialysis
The 9th Scientific Meeting of renal failure pathosis therapy
Masaaki Nakayama et.al.
2008
Electrolyzed water at cathode side (EW) suppressed renal injury in chronic kidney disease rats
Renal Week 2008, American Society of Nephrology?
Wan-Jun Zhu et.al.
2008
Growth suppression of HL60 and L6 cells by atomic hydrogen
The 21st Annual and International Meeting of Japanese Association for Animal Cell Technology 
K. Nakanishi et.al.
2008
Suppresive effects of hydrogen and atomic hydrogen on type 2 diabetes
The 21st Annual and International Meeting of Japanese Association for Animal Cell Technology 
K. Haramaki et.al.
2008
Supressive effect of electrolyzed reduced water on lipid peroxidation and lipid absorption
The 21st Annual and International Meeting of Japanese Association for Animal Cell Technology 
M. Abe et.al.
2008
Elongation of lifespan of nematode by electrolyzed reduced water
The 21st Annual and International Meeting of Japanese Association for Animal Cell Technology 
H. Yan et.al.
2008
Inducible effect of cancer cell death by electrolyzed -reduced water and it's model water
The annual meeting of West Japan of Japan Society for Bioscience, Biotechnology, and Agrochemistry 2008
K. Kadekaru et.al.
2008
Antidiabetic effect of electrolyzed -reduced water and it's model water
The annual meeting of West Japan of Japan Society for Bioscience, Biotechnology, and Agrochemistry 2008
K. Haramaki et.al.
2008
Examination of hemodialysis system using electrolyzed water
The 36th Scientific Meeting of the Tohoku renal failure 
Hiroshi Nemoto et.al.
2008
Investigation of biocompatibility about Hemodialysis solution (HD) by Electrolyzed water (EW)
The 53th Annual Meeting of the Japanese Society for Dialysis Therapy
Masaaki Nakayama et.al.
2008
Protective effect of electrolyzed cathodic water on diabetic nephropathy
The 8th Scientific Meeting of the Japanese Society of Anti-Aging Medicine
Takefumi Mori et.al.
2008
Potential of intake of electrolyzed water (Alkaline ion water) in countermeasure for chronic kidney disease
The 8th Scientific Meeting of the Japanese Society of Anti-Aging Medicine
Masaaki Nakayama et.al.
2008
Intake of electrolyzed cathodic water reduce excretion of urine protein of streptozotocin-induced diabetes Dahl S rat.
The 51st Annual Meeting of Japanese Society of Nephrology
Yusuke Osaki et.al.
2008
Investigation of participation of methylglyoxal on Cardiorenal syndrome
Vascular Medicine 2008 vol.4 no.4 345-351
Masaaki Nakayama et.al.
2008
Kinetic analysis of superoxide anion radical-scavenging and hydroxyl radical-scavenging activities of platinum nanoparticles.
Langmuir, June, Web on line
Takeki Hamasaki et.al.
2008
Examination of electrolyzed-reduced water on survival benefit of nematode
Annual Meeting of Japan Society for Bioscience, Biotechnology, and Agrochemistry 2008
H. Yan et.al.
2008
Suppressive effect of Electrolyzed-reduced Water on Lipid peroxidation and absorption
Annual Meeting of Japan Society for Bioscience, Biotechnology, and Agrochemistry 2008
Masumi Abe et.al.
2008
Inhibitory Effect of Electrolyzed Reduced Water on Tumor Angiogenesis
Biological & Pharmaceutical Bulletin 31(1),19-26, January
Jun YE et.al.
2008
Intake of water with high levels of dissolved hydrogen produced by electrolysis suppresses ischemia-induced cardio-renal injury in Dahl salt sensitive rats
Nephrology Dialysis Transplantation Dec 30th,2010 Web online
Wan-Jun Zhu et.al.
2010
Suppressive effects of electrolyzed reduced water on alloxan-induced apoptosis and type 1 diabetes Mellitus
Cytotechnology Nov 10th, 2010 Web online
Yupin Li et.al.
2010
Extension of the Lifespan of Caenorhabditis Elegans by Electrolyzed Reduced Water
Bioscience, Biotechnology, and Biochemistry 74(10),2011-2017,2010
Hankxu Yan et.al.
2010
Antioxidative effect of platinum nano particle on cultured animal cells
The 8th Annual Meeting of the Japanese society for functional water
Hidekazu Nakanishi et.al.
2010
Examination of mechanism of Sugar transport signal activation by model water for electrolyzed-reduced water
The 8th Annual Meeting of the Japanese society for functional water
Takeki Hamasaki et.al.
2010
Extension mechanism of the Lifespan of Caenorhabditis Elegans by Electrolyzed Reduced Water
The 8th Annual Meeting of the Japanese society for functional water
Tomoya Kinjou et.al.
2010
Hydrogen concentration and electrolyzed water-hemodialysis
The 55th Annual Meeting of the Japanese Society for Dialysis Therapy (Japan Kidney Week 2010)
Ryoichi Nakazawa et.al
2010
Evaluation of blood pressure on electrolyzed water-hemodialysis
The 55th Annual Meeting of the Japanese Society for Dialysis Therapy (Japan Kidney Week 2010)
Susumu Uemura et.al
2010
Development of new hemodialysis system by adding hydrogen(H2) to dialysate
The 53rd Annual Meeting of Japanese Society of Nephrology
Masaaki Nakayama et.al.
2010
Suppressive effect of drinking hydrogen dissolved water by water electrolysis on cardio-renal injury in CKD
The 10th Scientific Meeting of the Japanese Society of Anti-Aging Medicine
Wan-Jun Zhu et.al.
2010
A novel therapy suppressing oxidative stress and inflammation by hydrogen dissolved dialysate - hemodialysis system applied water electrolysis
The 10th Scientific Meeting of the Japanese Society of Anti-Aging Medicine
Masaaki Nakayama et.al.
2010
A novel bioactive hemodialysis system using dissolved dihydrogen(H2) produced by water electrolysis: A clinical trial
Nephrology Dialysis Transplantation Apr 12th,2010 Web online
Masaaki Nakayama et.al.
2010
Electrolysed-reduced water dialysate improves T-cell damage in end-stage renal disease patients with chronic haemodialysis
Nephrology Dialysis Transplantation Feb 26th,2010 Web online
Kuo-Chin Huang et.al.
2010
Methylglyoxal augments intracellular oxidative stress in human aortic endothelial cells.
Free Radical Research 2010 Jan;44(1):101-7.
Noriko Miyazawa et.al.
2010
Advanced research on the health benefit of reduced water
Trends in Food Science and Technology Web online
Sanetaka Shirahata et.al.
2011
The neuroprotective effects of electrolyzed reduced water and its model water containing molecular hydrogen and Pt nanoparticles
BMC Proceedings 2011, 5(Suppl 8):P69
Hanxu Yan et.al.
2011
Anti-diabetes effect of water containing hydrogen molecule and Pt nanoparticles
BMC Proceedings 2011, 5(Suppl 8):P18
Sanetaka Shirahata et.al.
2011
Protective Effect of Electrolyzed Water with High Dissolved Hydrogen (H2) on the Development of Cardiorenal Syndrome by Aging in Dahl Salt Sensitive Rat
Kidney Week 2011, American Society of Nephrology
Wan-Jun Zhu et.al.
2011
Protective Effect of Electrolyzed Water with High Dissolved Hydrogen (H2) on the Development of Cardiorenal Syndrome by Aging in Dahl Salt Sensitive Rat
The 13th China-Japan Joint Hypertension Symposium
Wan-Jun Zhu et.al.
2011
The mechanism analysis of the antioxidative effect by water containing hydrogen molecule or Pt nanoparticles
The 10th Annual Meeting of the Japanese society for functional water
Tomoya Kinjou et.al.
2011
Analysis of the cell death induction effect of model water for electrolyzed reduced water on human promyelocytic leukemia HL-60 cells
The 10th Annual Meeting of the Japanese society for functional water
T. Hamasaki et.al.
2011
Protective effect of electrolyzed water with high dissolved hydrogen (H2) on the development of cardiorenal syndrome by aging in dahl salt sensitive rat
The 10th Annual Meeting of the Japanese society for functional water
Wan-Jun Zhu et.al.
2011
Electrolyzed Water-Hemodialysis - Development of built-in production system for reversed osmosis purified electrolyzed water-
The 20th Annual Meeting of the Japanese Society for Next Generation of Artificial Kidney
Shigeru Kabayama et.al.
2011
Mechanism of the Lifespan Extension of Caenorhabditis elegans by Electrolyzed Reduced Water—Participation of Pt Nanoparticles
Bioscience, Biotechnology, and Biochemistry 75 (7), 110072-1–5, 2011
Hankxu Yan et.al.
2011
Examination of Blood Pressure on Electrolyzed Water Hemodialysis
The 56th Annual Meeting of the Japanese Society for Dialysis Therapy (Japan Kidney Week 2011)
Yoshie Mori et.al.
2011
Evaluation of nutrition on Electrolyzed Water-Hemodialysis
The 56th Annual Meeting of the Japanese Society for Dialysis Therapy (Japan Kidney Week 2011)
Susumu Uemura et.al.
2011
Hydrogen containing peritoneal dialysis solution
The 56th Annual Meeting of the Japanese Society for Dialysis Therapy (Japan Kidney Week 2011)
Shigeru Kabayama et.al.
2011
Examination of concentration of hydrogen on Electrolyzed Water-Hemodialysis
The 56th Annual Meeting of the Japanese Society for Dialysis Therapy (Japan Kidney Week 2011)
Yoichi Shimizu et.al.
2011
Intake of water with high levels of dissolved hydrogen produced by electrolysis suppresses ischemia-induced cardio-renal injury in CKD rats
The 54th Annual Meeting of Japanese Society of Nephrology
Wan-Jun Zhu et.al.
2011
Intake of electrolyzed water containg hydrogen suppresses age-related cardio-renal injury in CKD
The 11th Scientific Meeting of the Japanese Society of Anti-Aging Medicine
Wan-Jun Zhu et.al.
2011
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Also you are simply WRONG that we pressure people into paying big bucks. Most of us GIVE AWAY THE WATER FREELY and never have to twist anyone's arm to buy the machine. After people get off their meds, get pain-free, etc. they CHOOSE to buy the machine! For many of us, myself included, this water SAVED OUR LIVES. And yes that is TRUE. If anything, this water is UNDER-hyped, not over, because the reality is much more amazing than the stories you hear, but God forbid that anyone make any 'medical claims!'

Cheap competitor brands DO leach toxic metals into the water, because they don't use medical-grade components like we do.

Bottom line is that if you are going to review something, you really should base it on actual medical research, NOT on terminology mistakes made by distributors. Distributors aren't chemistry experts. They are simply sharing what has WORKED for them. If YOU were healed of a life-threatening illness, or your hair turned blonde again after being grey for several years, or you eliminated your diabetes, cholesterol, high blood pressure, etc. meds wouldn't YOU tell others?

How could you sleep at night if you didn't?

For that matter, you may wish to consider how many lives could potentially be impacted by your posting WRONG info on your site...Seriously, if you truly do have intentions to help others, then contact me and allow me to educate you. I mean that with all sincerity. You're just making the same mistakes commonly made by those who believe the DISinfo published by the drug companies. This water (and I mean the GENUINE, MEDICAL-GRADE water, NOT the knockoffs who use our name) can withstand the toughest scrutiny.

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