Everybody has their own timeline of detox, so unfortunately it's hard to know what you may expect. I had difficulty at low doses, and thought I was poisoning myself. My version was vicious headaches. After I found this site, I discovered I wasn't poisoning myself, I was in detox. That was a relief. Then I was able to stay on it, and drink my water and take my supplements, and got past the headache stage. I kept increasing my dose, doing okay between 50-100 mg, then at 150 mg Iodoral I landed in a black depression I was very familiar with. I cut the Iodoral in half and added an equivalent amount of SSKI, and that gave me relief. Ever since, I've used a combo of Iodoral and SSKI to best effect.
Your detox may take on its own personality. You may have pains in your body that revisit sites of old injuries. Three times my husband's smallpox vaccination scar acted up. And my last tetanus shot site hurt so much I thought I'd just been injected. Bromine will come out your skin. You may have bad breath, foul armpits, stinky sweat. As you can become braver, take more iodine. You might investigate buying SSKI or making your own to partner with the Iodoral. SSKI may be a little gentler on your system, and you can raise faster. As you get to 100 mg, you'll probably get over the hump, and detox will just be noticed, not knock you over the head.
I don't know if this is encouraging, or discouraging :) But detox is not endless, that I know. If you get overwhelmed, stop for a few days, a week, whatever you need. Keep drinking and sweating, and slowly you'll gain ground.