1989-2011 C albicans: Disrupting or Blocking Morphogenisis

1989-2011 C albicans: Disrupting or Blocking Morphogenisis
Research Article excerpts. Click link to read more

1989 Involvement of a Ca2+-calmodulin interaction
in the yeast-mycelial (Y-M) transition
of Candida albicans [3153A]
http://www.springerlink.com/content/n173387646671h32/

>>A yeast-mycelium (Y-M) transition
of Candida albicans (3153A)
was induced by 1.5 mM CaCl2 • 2H2O
in defined liquid medium, pH 7, at 25 °C.

Non-toxic concentrations
of the calmodulin inhibitor R24571
almost completely
suppressed germ tube formation …

2000 Undecylenic acid inhibits morphogenesis
of Candida albicans.
http://www.ncbi.nlm.nih.gov/pubmed/10991877

>>Resilient liners are frequently used
to treat denture stomatitis,
a condition often associated with Candida albicans infections.

>>Of 10 liners tested,
2 were found to inhibit the switch
from the yeast form to hyphae and
a third was found to stimulate this switch.
The inhibitor was determined to be undecylenic acid.

2007 Candicidal action of resveratrol
isolated from grapes
on human pathogenic yeast C. albicans.
http://www.ncbi.nlm.nih.gov/pubmed/18051601

>>It was found that the serum-induced mycelial forms,
which play a crucial role in the pathogenesis
of C. albicans
during host tissue invasion,
were disrupted by resveratrol.

2010 Resveratrol
impaired the morphological transition
of Candida albicans
under various hyphae-inducing conditions.
http://www.ncbi.nlm.nih.gov/pubmed/20519919

>>In this study, we investigated
the antifungal activity of resveratrol
against C. albicans.
Both yeast-form and mycelial growth
of C. albicans were inhibited by resveratrol.

>>In addition,
normal filamentation of C. albicans
was affected and yeast-to-hypha transition
under serum-, pH-, and nutrient-induced
hyphal growth conditions
was impaired by resveratrol

2011 Blocking of Candida albicans biofilm formation by cis-2-dodecenoic acid and trans-2-dodecenoic acid [drugs].
http://www.ncbi.nlm.nih.gov/pubmed/21778264

>>The biofilm enhances the resistance
of the C. albicans defence system,
increases its resistance to antifungal drugs and
induces increased drug tolerance,
making clinical care more challenging.

>>[None of the four drugs]
(BDSF, trans BDSF, farnesol,
cis-11-methyl-2-dodecenoic acid)
was able to destroy pre-formed biofilms.

>>[…] implying that BDSF and trans-BDSF
block C. albicans biofilm formation
by interfering with the morphological switch.