I've been going through this crying at the drop of a hat Depression thing for the past few days after having what felt like a minor adrenal crash at the onset (dizzy, nauseous, kidney pain, cold sweats). I'm standing in the shower crying for no apparent reason and it hits me that my seratonin level must be off. I really had no reason to feel this depressed and I do tons of energy work to help with these types of issues but for some reason it wasn't budging. So I picked up some NOW 200mg 5HTP at my local HF store. I had the feeling that putting some under my tongue would be a straighter path to the brain so I tried it. Right away I had a slight feeling of mood change and a few hours later I'm laughing and back to myself like nothing ever happened. In fact it's been a long time since I've felt this good. So for those of you are hitting a wall with Depression taking 5HTP sublingually might be the ticket. I read somewhere that 5HTP gets broken down to 5HT in the stomach/DI tract and you lose some effectiveness that way so this might be a quicker way to get some results. I would consider starting with a lower dosage under the tongue like 50mg and see how it feels. Hope this helps some of you.