I had this bigtime as my adrenals got worse, before putting myself on Isocort & then consequently before working w/ Dorine.
I found it was thyroid related in fact.
I found that although Isocort helped w/ many symptoms, it did not the all encompassing bladder issues.
I read Dr Lowe's info on Hypothyroidism and how much he gives patients to help w/ Chronic-Fatigue-Syndrome etc
I tried upping the 3x . 05 mcg I'd been on most of my life and 'Voila" bladder fixed immediately
I also noticed now while working w/ Dorine that as I wean off all the extra Cytomel at times my bladder would flare up if things were not strong enough to cope w/ the tapering off.
So - yeah, you probably know Thyroid is often affected secondarily to adrenal fatigue - that was def the case w/ me and I had to supplement 'till things got stronger.