Yes I get this sensation too. Like a burning pain in my bladder when its full. It could be toxins causing irritation. Thats what I put it down to anyway (having ruled out any bladder infections).

My prostate and bladder always burn. In fact, I feel like I have something the size of a miniature toy car stuck up my ass 24x7 : )

Have you tried drinking aloe vera juice at night? I drink Georges distilled aloe, it's very soothing on the bladder and intestines.

I had this bigtime as my adrenals got worse, before putting myself on Isocort & then consequently before working w/ Dorine.

I found it was thyroid related in fact.

I found that although Isocort helped w/ many symptoms, it did not the all encompassing bladder issues.

I read Dr Lowe's info on Hypothyroidism and how much he gives patients to help w/ Chronic-Fatigue-Syndrome etc

I tried upping the 3x . 05 mcg I'd been on most of my life and 'Voila" bladder fixed immediately

I also noticed now while working w/ Dorine that as I wean off all the extra Cytomel at times my bladder would flare up if things were not strong enough to cope w/ the tapering off.

So - yeah, you probably know Thyroid is often affected secondarily to adrenal fatigue - that was def the case w/ me and I had to supplement 'till things got stronger.

Hope this helps.