I agree with Southern Belle. Take the meds in the morning, and do the flush that evening.
It could take up to 20-30 flushes to get everything out, especially if she has a congested liver/gall bladder like I do. I've done 5 flushes so far and have only gotten about 80 stones out. I have been dealing with headaches/migraines for almost 6 years, and what has helped me with them is colonics. My colon hydrotherapist said that I have a bulging/clogging in my transverse colon. After a colonic I have no headaches for about 10 days. I've got to get my colon clean and change my eating habits. Maybe your wife's problem is her colon too. I don't know, but it's worth the try.