Everything done to nature has an impact. Antibiotics cannot be removed from wasted waters. Nor can oestrogens, from the urine of all women who took 'the pill' in order to have sex and not get pregnant. (no judgement here...)
The fishes in the lakes and rivers are turning mainly female due to that. And I truely believe it is linked to age of puberty getting lower. Infertility is also linked to that.
Not only the oestrogens from 'the pill', but also the xeno oestrogens: from car windshields mainly.