It should be safe to do one now. The Epsom Salts should open things up. If you are in pain now, you may want to try the Epsom Salts and see if the pain goes away. Then you have the choice of either going ahead with the rest of the Liver Flush or waiting till the end of May, or doing it some time in between. People often take a dose of Epsom Salts when they get gallbladder pain.,