I remember reading about bad wrinkles around the eyes being a symptom of one of these. Like when you smile on the outside of your eyes there is tons of wrinkles.
I had "crazy sex" with this girl from chile who looked sickly and I remember thinking "why the hell are her eyes so wrinkled?" and just her face in general looked tired.
I noticed this with myself now and I have pics of me a few years ago where my skin is tight and I look healthy. Also hair growth on the face where it shouldn't be (top of nose, maxillary sinus area, under eyes) and pitting in the maxillary sinus area.
I am starting to notice this with people close to me as well. The people who complain of feeling tired, sick etc... all seem to have this in common.
I need to figure out where I read this.... unless one of you know.