I started taking one iodoral a day and then experimented and three seemed to be the perfect dosage for me. Within I would say six months I noticed a considerable improvement where I believed I may not need my medication any longer and I withdrew it on my own. Now, I don't know if this is advisable and when withdrawing any medications such as these, I would definitely seek advice, but in my case I had no support so I just did it on my own. Luckily, I still felt fine. I would say that I noticed the difference in six months and by a year I was fine and still am today, although now I take magnascent and SSKI. Now I will point out that during this time I changed my diet to a healthy one. It consisted of 80% raw, fruits and veggies, and 20% cooked, consisting of chicken, turkey, and fresh water fish.