Oleander is also very poisonous, but grown extensivly, it is also used as a medicinal plant.
Yes, it was once widely used as a heart drug. I was doing some experiments with it a long time ago trying to make cardiac drugs without all the side effects. To make a long story short, one whiff bottomed out my blood pressure for several hours and you could not find a pulse anywhere on me, even with drinking caffeine.
There was also a case here a few years back where a guy was burning a pile of oleander leaves. His dog ran through the smoke killing the dog instantly.
The entire plant is poisonous, even the honey made from it.