I actually have run out because I was taking them until my order came for my other things had ordered from the health store.. They did come yesterday. Actually no because I started my primadolphilus with Bifudus that contains Lactobacillus acidolphilus, Lact.Rhamnosus,B.longum.and the B.breve. I'm taking Florastor (it's suppose to help yeast infections) so since the Primadolphilus has it I may wait until I run out or just get the one from GNC to just have it,I don't want to take too many things in that way I'll see what's working and what's not. Because I noticed I have symptoms problems related to a leaky Gut I'm beginning to wonder if that may be part of my problem. And then I had started taking antibiotics probiotic from GNC because of a respiratory ailment. But I should have waited until I finished the antibiotics although it did help with the yeast problem and the breath odor. So for right now I'm just taking those 2 probiotics, golden seal,bromelian and some digestive enzymes,and a multivitamin.