Last time I was at my doctor feeling lousy, he said if it didn't improve, he was pretty much out of ideas, and would refer me to either Mayo or the Univ of MN (I live in a suburb of Minneapolis). Thankfully I've been feeling better the last couple months, but if it goes downhill again, I would definately go to Mayo. I have 2 close family members that have greatly benefitted from going there, and an aunt who works there. Keep us posted if you go, I would be very interested to hear what they come up with for you.