I took 1 dose at 1 time. the caps I bought were 600mg so I took 10 coq10 pills with 10 fish oil pills. I took them first thing in the morning on an empty stomach. Invest in some Black-Walnut and take that for a couple months. If anyone has any specific questions then shoot me mail. I just dont want anyone to go through the hell I went through for 27 years.