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I am doing the cutler protocol again, every 4 hrs but 12 1/2 mg is too much for me. i need to go slow because I don't think i can go to work today.
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Try taking it every two hours during the day, if that helps then start with 2x500mg Niacinamide 3x per day, and maybe some liver support. It suggests your Phase I liver function is out of whack with Phase II.