In the beginning and especially if Lead is an issue you may want to add Enzymes to help with digestion. The combo of Mercury and Lead kill over 1800 enzymatic functions.
Another that helps is Taurine, to limit reabsorbtion of bile and of course water soluble fiber like Konjacu: http://www.konjacfoods.com/
Might also want to look at some of my prior posts on Magnesium Malate in this forum...